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J. Hefei Univ. Tech. (Nat. Sci.)

合肥工业大学学报(自然科学版)

JOURNAL OF HEFEI UNIVERSITY OF TECHNOLOGY (NATURAL SCIENCE)

Competent Authorities: Ministry of Education of the People's Republic of China

Sponsor by: Hefei University of Technology

ISSN 1000-1646, CN 34-1001/N

Synthesis, derivatization and separation of menthol isomers with optical activity

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光学活性薄荷醇异构体的合成、衍生及分离

Journal Information

J. Hefei Univ. Tech. (Nat. Sci.), Nov.2023, Vol.46 No.11: 1542-1548

DOI: 10.3969/j.issn.1003-5060.2023.11.017

Authors

GE Guangqiong, FU Yanming, SHEN Hao, WU Xiang, ZHU Chengfeng, LI Yougui

(School of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei 230009, China)

Abstract and Keywords

Abstract: L-menthol is an important spice which has been widely used in food and pharmaceutical industry, however, each stereoisomer presents different properties due to the three chiral centers in its structure. At the same time, it is difficult to obtain optically active menthol isomers because of the limited development of the separation technology. In this paper, single isomer was synthesized from the pure menthol with optical activity and further esterification derivatization was carried out. Based on this, a relatively efficient chiral liquid phase separation method was determined.

Keywords: L-menthol; isomer; optical activity; esterification derivatization; separation method

作者信息

戈光琼，付延明，沈昊，吴祥，朱成峰，李有桂

（合肥工业大学化学与化工学院，安徽合肥230009）

摘要和关键词

摘要: L薄荷醇是一种广泛应用于食品和医药行业的重要香料，因其结构中存在3个手性中心，使得每种立体异构体呈现不同的性质；同时由于现有工艺发展的局限性，较难获得光学活性的薄荷醇异构体。文章从具有光学活性的薄荷醇出发，合成得到单个异构体，并对其进行酯化衍生反应，基于此，确定了相对高效的手性液相分离方法。

关键词: L-薄荷醇；异构体；光学活性；酯化衍生；分离方法

Funding

安徽省自然科学基金资助项目（2108085QE233）

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