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J. Hefei Univ. Tech. (Nat. Sci.)

合肥工业大学学报(自然科学版)

JOURNAL OF HEFEI UNIVERSITY OF TECHNOLOGY (NATURAL SCIENCE)

Competent Authorities: Ministry of Education of the People's Republic of China

Sponsor by: Hefei University of Technology

ISSN 1000-1646, CN 34-1001/N

Effects of juvenile bisphenol F exposure on spatial working memory of mice

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幼年期双酚 F 暴露对小鼠空间工作记忆的影响

Journal Information

J. Hefei Univ. Tech. (Nat. Sci.), Sept.2024, Vol.47 No.9: 1236-1242

DOI: 10.3969/j.issn.1003-5060.2024.09.012

Authors

WANG Ziyan, LUO Tianyu, WANG Ye, ZHU Benshan, HU Fan

(School of Food and Biological Engineering, Hefei University of Technology, Hefei 230601, China)

Abstract and Keywords

Abstract: There are relatively few studies on the effects of bisphenol F(BPF), the main substitute for bisphenol A(BPA), on brain learning and memory, especially spatial working memory. In this paper, juvenile(21-49 d) was used as a time window to study the effects of BPF exposure on spatial working memory of mice through different behavioral paradigms and immunoblotting experiments. The study found that $ 1 \, \text{mg}/(\text{kg} \cdot \text{d}) $ BPF exposure did not affect the physiological status of mice such as body weight and water intake, and did not affect the basic exercise ability of mice, but it did damage to the spatial working memory ability of mice. In the T-maze 40 s test, the correct rate of the BPF group was significantly lower than that of the control group; in addition, the expression of GluR2 in the prefrontal cortex (PFC) glutamate receptor protein was significantly lower than that of the control group. These results suggest that juvenile BPF exposure impairs the spatial working memory ability of mice, which may be related to the decreased expression of the excited receptor subunit GluR2. This study will provide valuable information on BPF-induced neurological damage and provide a rationale for the selection of BPA substitutes in industrial production.

Keywords: bisphenol F(BPF); spatial working memory; bisphenol A(BPA); prefrontal cortex(PFC); juvenile

作者信息

王子炎，罗天宇，王烨，朱本山，胡繁

（合肥工业大学食品与生物工程学院，安徽合肥230601）

摘要和关键词

摘要: 双酚 F(BPF) 作为双酚 A(BPA) 的主要替代物, 对大脑学习记忆的影响, 特别是空间工作记忆的研究相对较少。文章以幼年期(21~49 d) 为时间窗口, 通过不同的行为学范式及免疫印迹实验研究 BPF 暴露对小鼠空间工作记忆的影响。研究发现, $ 1 \, \text{mg}/(\text{kg} \cdot \text{d}) $ BPF 暴露不会影响小鼠的体质量、饮水量等生理状态和小鼠基本的运动能力, 但对小鼠的空间工作记忆能力有损害。在 T 迷宫 40 s 测试中, BPF 组的正确率显著低于对照组小鼠; 前额叶皮层 (prefrontal cortex, PFC) 谷氨酸受体蛋白中 GluR2 表达量显著低于对照组。结果表明, 幼年期 BPF 暴露损害小鼠的空间工作记忆能力可能与兴奋性蛋白受体亚基 GluR2 表达量降低有关。该研究将为 BPF 引起的神经系统损伤提供了有价值的信息, 并在工业生产中为 BPA 替代物的选择提供了理论依据。

关键词: 双酚 F(BPF)；空间工作记忆；双酚 A(BPA)；前额叶皮层(PFC)；幼年期

Funding

国家自然科学基金资助项目（21876041）

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