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J. Hefei Univ. Tech. (Nat. Sci.)

合肥工业大学学报(自然科学版)

JOURNAL OF HEFEI UNIVERSITY OF TECHNOLOGY (NATURAL SCIENCE)

Competent Authorities: Ministry of Education of the People's Republic of China

Sponsor by: Hefei University of Technology

ISSN 1000-1646, CN 34-1001/N

β-HB relieves liver lipid deposition caused by bisphenol A

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β-羟基丁酸缓解双酚 A 致肝脏脂质沉积

Journal Information

J. Hefei Univ. Tech. (Nat. Sci.), Aug. 2026, Vol.49 No.8: 1130-1134

DOI: 10.3969/j.issn.1003-5060.2026.08.018

Authors

WANG Mengya, GU Xiaozhen

(School of Food and Biological Engineering, Hefei University of Technology, Hefei 230601, China)

Abstract and Keywords

Abstract: Bisphenol A (BPA) is an environmental endocrine disruptor that can cause disturbances in liver lipid metabolism. During fasting, $ \beta $-Hydroxybutyrate ( $ \beta $-HB) is the primary ketone body produced through fatty acid $ \beta $-oxidation to supply energy. This paper investigates the effect of $ \beta $-HB intake on the liver of mice exposed to BPA and the underlying mechanisms. C57 mice were used and divided into four groups: control, BPA, $ \beta $-HB, and $ \beta $-HB+BPA. The lipid deposition in mice was identified through HE and Oil Red O staining. The experimental results showed that compared with the blank control group, the BPA group induced liver lipid accumulation in mice, while $ \beta $-HB supplementation alleviated lipid accumulation caused by BPA exposure through inhibiting histone deacetylase HDAC2. This study helps to enhance public understanding of the impact of environmental pollution on health, and provides new strategies for the treatment of liver lipid metabolism disorders caused by environmental factors.

Keywords: environmental endocrine disruptors (EEDs); $ \beta $-Hydroxybutyrate ( $ \beta $-HB); bisphenol A (BPA); liver; lipid metabolism

作者信息

王梦雅，谷小珍

（合肥工业大学食品与生物工程学院，安徽合肥230601）

摘要和关键词

摘要: 双酚 A(BPA)是一种环境内分泌干扰物, 可导致肝脏脂质代谢紊乱, 而 $ \beta $-羟基丁酸( $ \beta $-HB)是在禁食期间, 主要由脂肪酸 $ \beta $ 氧化供应能量而产生的酮。文章研究了 $ \beta $-HB 的摄入对双酚 A 暴露小鼠肝脏的影响, 并分析了其影响机制。该研究将 C57 小鼠分为对照组、BPA 组、 $ \beta $-HB 组、 $ \beta $-HB+BPA 组, 通过 HE 和油红 O 染色以鉴定小鼠体内的脂质沉积。实验结果表明, 与空白对照组相比, BPA 组在小鼠体内产生肝脏脂质积聚, 而补充的 $ \beta $-HB 可通过抑制组蛋白去乙酰化酶 HDAC2 来缓解 BPA 暴露导致的脂质沉积。该研究有助于提升公众对环境污染健康危害的认知, 也为环境因素致肝脏脂质代谢损伤的治疗提供了理论依据。

关键词: 环境内分泌干扰物； $ \beta $-羟基丁酸( $ \beta $-HB)；双酚A(BPA)；肝脏；脂质代谢

Funding

国家自然科学基金资助项目（82273666）

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