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新型聚合物纳米造影剂的合成及 体内磁共振成像研究

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Synthesis of novel polymer nano-contrast agents and study of in vivo magnetic resonance imaging

期刊信息

合肥工业大学（自然科学版），2023年2月，第46卷第2期：241-245

DOI: 10.3969/j.issn.1003-5060.2023.02.015

作者信息

孙天赐 $ ^{1} $，杨怀 $ ^{1} $，闫旭 $ ^{1} $，方蔚伟 $ ^{1} $，张培松 $ ^{2} $，何涛 $ ^{1} $

(1. 合肥工业大学化学与化工学院，安徽合肥 230009；2. 武警安徽省总队医院 普外三科，安徽合肥 230061)

摘要和关键词

摘要: 文章采用可逆加成-断裂链转移聚合（reversible addition-fragmentation chain transfer polymerization，RAFT）方法，聚合得到以疏水性共聚物链段作为内核，亲水性共聚物链段作为支链的两亲性聚合物纳米颗粒，与氯化钆（Ⅲ）六水合物进行螯合反应后合成了一种新型的支化结构聚合物磁共振成像（magnetic resonance imaging，MRI）纳米造影剂P（DO3A-Gd $ ^{3+} $）。安全性试验结果表明，P（DO3A-Gd $ ^{3+} $）具有良好的生物安全性。体外MRI测试结果表明：P（DO3A-Gd $ ^{3+} $）的弛豫率为5.30（mmol/L） $ ^{-1} $·s $ ^{-1} $，高于临床造影剂Magnevist（2.94（mmol/L） $ ^{-1} $·s $ ^{-1} $）；P（DO3A-Gd $ ^{3+} $）具有显著的MRI造影增强效果。研究结果表明P（DO3A-Gd $ ^{3+} $）是一种优异的MRI造影剂，具有临床转化的潜力。

关键词: 聚合物纳米；磁共振成像（MRI）；纳米造影剂；生物安全性；临床转化

Authors

SUN Tianci $ ^{1} $, YANG Huai $ ^{1} $, YAN Xu $ ^{1} $, FANG Weiwei $ ^{1} $, ZHANG Peisong $ ^{2} $, HE Tao $ ^{1} $

(1. School of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei 230009, China; 2. The Third Department of General Surgery, Anhui Provincial Armed Police Corps Hospital, Hefei 230061, China)

Abstract and Keywords

Abstract: In this paper, a reversible addition-fragmentation chain transfer polymerization (RAFT) method was used to polymerize amphiphilic polymer nanoparticles with hydrophobic copolymer segments as the core and hydrophilic copolymer segments as the branched chains. A new branched structure polymer magnetic resonance imaging (MRI) nano-contrast agent P(DO3A-Gd $ ^{3+} $) was synthesized after chelating reaction of GdCl $ _{3} $·6H $ _{2} $O. The safety test results show that P(DO3A-Gd $ ^{3+} $) has good biosafety. In vitro MRI test results show that the relaxation rate of P(DO3A-Gd $ ^{3+} $) is 5.30 (mmol/L) $ ^{-1} $·s $ ^{-1} $, which is higher than that of the clinical contrast agent Magnevist(2.94 (mmol/L) $ ^{-1} $·s $ ^{-1} $). In vitro MRI test results show that P(DO3A-Gd $ ^{3+} $) has a significant MRI contrast enhancement effect. The results show that P(DO3A-Gd $ ^{3+} $) is an excellent MRI contrast agent and has the potential for clinical transformation.

Keywords: polymer nanoparticles; magnetic resonance imaging(MRI); nano-contrast agent; biosafety; clinical transformation

基金信息

国家自然科学基金资助项目（21574035）

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