合肥工业大学校徽

合肥工业大学学报自科版

合肥工业大学学报(自然科学版)

JOURNAL OF HEFEI UNIVERSITY OF TECHNOLOGY (NATURAL SCIENCE)

主管：中华人民共和国教育部

主办：合肥工业大学

ISSN 1003-5060, CN 34-1083/N

脂肪体特异敲低Catsup通过调控细胞内锌水平影响肠道发育

Fat body-specific knockdown of Catsup affects intestinal development by regulating intracellular zinc level

期刊信息

合肥工业大学（自然科学版），2026年3月，第49卷第3期：360-364

DOI: 10.3969/j.issn.1003-5060.2026.03.012

作者信息

陈颖，肖桂然，高佳佳

（合肥工业大学食品与生物工程学院，安徽合肥230601）

摘要和关键词

摘要: 锌是人体必需的微量营养素之一,参与人体生长和器官发育中的多数生理过程。研究发现生物体的不同器官之间存在通讯联系,但具体机制尚不清楚。文章以哺乳动物锌转运蛋白ZIP7的果蝇同源物Catsup为切入点,发现在脂肪体(相当于哺乳动物肝脏)特异性敲低Catsup会导致果蝇中肠变短、表面积减少等肠道发育异常问题;通过膳食手段和遗传手段调控锌水平可以挽救脂肪体Catsup敲低导致的上述肠道异常表型。研究结果表明,脂肪体内Catsup表达调控的锌稳态对于肠道发育是必须的,并为进一步探究不同器官之间联系的生理机制提供了理论依据。

关键词: 果蝇；锌；Catsup；脂肪体；肠道

Authors

CHEN Ying, XIAO Guiran, GAO Jiajia

(School of Food and Biological Engineering, Hefei University of Technology, Hefei 230601, China)

Abstract and Keywords

Abstract: Zinc is one of the essential micronutrients of human body, and it is involved in many physiological processes of human growth and organ development. Studies have found that there are communication links between different organs of organisms, but the specific mechanism is not clear. Based on Catsup, a homolog of mammalian zinc transporter ZIP7 in Drosophila melanogaster, it was found that specific knockdown of Catsup in the fat body (equivalent to mammalian liver) resulted in intestinal abnormalities, including midgut shortening and surface area reduction. Dietary and genetic regulation of zinc levels can rescue the above intestinal abnormal phenotypes caused by Catsup knockdown in fat body. These results suggest that zinc homeostasis regulated by Catsup expression in fat body is essential for intestinal development, and provide a theoretical basis for further exploring the physiological mechanism of the links between different organs.

Keywords: Drosophila; zinc; Catsup; fat body; intestines

基金信息

国家自然科学基金资助项目（32170576）

前一篇后一篇

返回期刊目录