Abstract: To investigate the effects of Cheng Shi Juan Bi Tang(CSJBT) on oxidative stress in adjuvant arthritis(AA) rats, complete Freund's adjuvant(CFA) was used to induce SD rats to establish arthritis model. The animals were randomly divided into normal group, model group, glycosides of Tripterygium wilfordii(GTW) group(0.01 g/kg) and CSJBT groups(2.55, 5.10, and 10.20 g/kg, respectively). The rats were given intragastric administration on the 15th day after modelling for two weeks. The effects of CSJBT on paw swelling degree, body weight and oxidative stress related indexes of AA rats were investigated, and its effects on joint histopathological changes of AA rats were observed by haematoxylin and eosin(HE) staining method. The results showed that CSJBT could alleviate joint swelling, increase body weight, and improve synovial histopathological changes of AA rats. And CSJBT could reduce the production of reactive oxygen species(ROS) in synovial tissues and the levels of inducible nitric oxide synthase(iNOS) and malondialdehyde(MDA) in serum, while increasing the levels of superoxide dismutase(SOD), catalase(CAT), glutathione peroxidase(GSH-Px) and glutathione(GSH) of AA rats. These results indicated that CSJBT had a good inhibitory effect on the oxidative stress response in AA rats.
Keywords: Cheng Shi Juan Bi Tang (CSJBT); adjuvant arthritis (AA) rat; reactive oxygen species (ROS); oxidative stress
合肥工业大学学报自科版