Abstract: There are few researches on the effects of bisphenol F(BPF), the main substitute of bisphenol A(BPA), on brain function. This paper chose the juvenile(21-49 d) as exposure time window to study the effects of BPF on the behavior of mice through different behavioral paradigms. The results showed that $ 1 \, \text{mg}/(\text{kg} \cdot \text{d}) $ BPF treatment did not affect the physiological status of mice, such as body weight and water consumption, but significantly reduced the time and frequency of mice entering the central area in open field test, increased the immobile time of mice in tail suspension test and forced swimming test and weakened the sniffing time with strange mice 1 while the social novelty with strange mice 2 had no changes in three-chamber test. Those results suggested that juvenile BPF exposure could induce anxiety-and depressive-like behaviors and impair the social ability of mice. This paper will provide valuable information for BPF-induced nervous system impairments and provide theoretical basis for industrial production choosing BPA alternative as raw material.
Keywords: bisphenol F(BPF); bisphenol A(BPA); anxiety; depression; social
合肥工业大学学报自科版