合肥工业大学校徽

合肥工业大学学报自科版

合肥工业大学学报(自然科学版)

JOURNAL OF HEFEI UNIVERSITY OF TECHNOLOGY (NATURAL SCIENCE)

主管：中华人民共和国教育部

主办：合肥工业大学

ISSN 1003-5060, CN 34-1083/N

黑豆皮提取物对果蝇结肠炎的保护作用

Protective effect of black bean seed coat extract on Drosophila colitis

期刊信息

合肥工业大学（自然科学版），2024年5月，第47卷第5期：685-689

DOI: 10.3969/j.issn.1003-5060.2024.05.017

作者信息

瞿涛，肖桂然

（合肥工业大学食品与生物工程学院，安徽合肥230601）

摘要和关键词

摘要: 黑豆是东方医学中常见的药食同源材料, 黑豆皮提取物(black bean seed coat extract, BBSCE)含有高浓度的酚类化合物, 具有很好的抗氧化和抗炎症活性。文章采用十二烷基硫酸钠(sodium dodecyl sulfate, SDS)诱导的果蝇溃疡性结肠炎研究 BBSCE 对肠道损伤的防御作用。研究发现, 果蝇在 SDS 暴露实验中, 其存活率、攀爬能力以及肠道形态会受到显著影响, 肠道屏障的完整性也会受到严重破坏。膳食喂养 BBSCE 可以有效地减轻 SDS 暴露对果蝇造成的损害, 包括行为学损伤、肠道形态及肠道屏障的完整性。结果表明, BBSCE 可以通过改善肠道萎缩和提高肠道屏障的完整性保护肠道免受化合物造成的损伤, 可为功能性食品或天然药物的开发提供理论依据。

关键词: 果蝇；溃疡性结肠炎；黑豆皮提取物（BBSCE）；肠道形态；肠道屏障完整性

Authors

QU Tao, XIAO Guiran

(School of Food and Biological Engineering, Hefei University of Technology, Hefei 230601, China)

Abstract and Keywords

Abstract: Black bean is a common medicinal and edible homologous material in oriental medicine, and the black bean seed coat extract (BBSCE) contains a high concentration of phenolic compounds, with good antioxidant and anti-inflammatory activities. The protective effect of BBSCE on intestinal injury was studied based on Drosophila ulcerative colitis induced by sodium dodecyl sulfate (SDS). It was found that the survival rate, climbing ability and intestinal morphology of Drosophila were significantly affected by SDS exposure, and the integrity of the intestinal barrier was severely damaged. Dietary BBSCE could effectively reduce the damage caused by SDS exposure to Drosophila, including behavioral damage, intestinal morphology and intestinal barrier integrity. These results indicate that BBSCE can protect the gut from damage caused by compounds by improving the intestinal atrophy and the integrity of the intestinal barrier, which can provide a theoretical basis for the development of functional foods or natural drugs.

Keywords: Drosophila; ulcerative colitis; black bean seed coat extract(BBSCE); intestinal morphology; intestinal barrier integrity

基金信息

国家自然科学基金资助项目（32170576）；安徽省重点研究与开发计划资助项目（2022i01020007）

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