Abstract: There are relatively few studies on the effects of bisphenol F(BPF), the main substitute for bisphenol A(BPA), on brain learning and memory, especially spatial working memory. In this paper, juvenile(21-49 d) was used as a time window to study the effects of BPF exposure on spatial working memory of mice through different behavioral paradigms and immunoblotting experiments. The study found that $ 1 \, \text{mg}/(\text{kg} \cdot \text{d}) $ BPF exposure did not affect the physiological status of mice such as body weight and water intake, and did not affect the basic exercise ability of mice, but it did damage to the spatial working memory ability of mice. In the T-maze 40 s test, the correct rate of the BPF group was significantly lower than that of the control group; in addition, the expression of GluR2 in the prefrontal cortex (PFC) glutamate receptor protein was significantly lower than that of the control group. These results suggest that juvenile BPF exposure impairs the spatial working memory ability of mice, which may be related to the decreased expression of the excited receptor subunit GluR2. This study will provide valuable information on BPF-induced neurological damage and provide a rationale for the selection of BPA substitutes in industrial production.
Keywords: bisphenol F(BPF); spatial working memory; bisphenol A(BPA); prefrontal cortex(PFC); juvenile
合肥工业大学学报自科版