牛乳铁蛋白肽对肠道肿瘤的抑制作用

牛乳铁蛋白肽（LfcinB）是由牛乳铁蛋白水解产生的一种天然抗菌肽，已被证实具有抗菌、抗肿瘤和抗病毒等多种功效。近年来，果蝇已成为研究肿瘤诱导宿主消耗的理想模型。文章利用经典模式生物果蝇肠道中过表达活化的转录因子 $ yki^{3SA} $ （人体 YAP1 同源物），诱导肠道干细胞过度增殖构建肠道恶性肿瘤模型，探究 LfcinB 对恶性肿瘤的影响。结果发现，LfcinB 能够显著延长 $ yki^{3SA} $ 诱导的肠道肿瘤果蝇模型的寿命，并改善由肿瘤导致的腹部肿胀、肠道形态异常和肠道通透性损伤。研究表明，LfcinB 在预防和治疗肿瘤方面具有潜在应用价值和指导意义。

Bovine lactoferricin(LfcinB) is a natural antimicrobial peptide produced by the hydrolysis of bovine lactoferrin. It has been proven to have antibacterial, anti-tumor and anti-viral effects. Drosophila melanogaster has recently emerged as an ideal model for studying tumor-induced host depletion. In this study, $ yki^{3SA} $ (human YAP1 homolog) was overexpressed in the gut of the classic Drosophila melanogaster model to induce the overproliferation of intestinal stem cells to construct an intestinal malignant tumor model, and the effect of LfcinB on malignant tumors was investigated. It is found that LfcinB can significantly prolong the life span of the $ yki^{3SA} $-induced intestinal tumor Drosophila melanogaster model. It can also improve abdominal swelling, abnormal intestinal morphology and intestinal permeability injury caused by tumors. Taken together, this work demonstrates the potential application and guiding significance of LfcinB in the prevention and treatment of tumors.